Jan 14, 1996 Mark Konlee
This newsletter has been expanded to 24 pages instead of the usual 16 because of very new and significant discoveries and developments since Sept., 1995. On Jan. 7th, 1996, I finally completed a major revision of my book - How To Reverse Immune Dysfunction. The new edition is the 4th revision since Feb., 1995. Most of the new information from the new edition has been reprinted in this newsletter. It includes two significant changes.
First, the book has decoupled itself from protocols primarily designed to increase CD4 Helper cell counts to protocols designed to increase more important immune cells in dealing with AIDS and Chronic Fatigue Syndrome(CFS) - namely the Natural Killer cells and the Killer T cells (CD8s). In the previous two issues of this newsletter, I reported on the phenomenon of thousands of PWAs with zero CD4 counts who were living many years in good health and indicated that I thought that this was due to some unknown subsets of immune cells called non-specific effector cells that could keep opportunistic infections at bay. Based on the latest research in immunology, these subsets of immune cells have been identified as the Natural Killer (NK) cells and the Killer T cells, a subset of CD8 cells.
Significant scientific research now indicates that both the NK and CD8 cells can destroy cells infected with one or both of the two viruses that cause AIDS - HIV and HHV-6A. The immune system is not effective in lowering the viral loads because of a defect in the B cell function - the inability to produce neutralizing antibodies. This is why our emphasis has shifted from increasing CD4 cell counts to increasing CD8 and NK cell activity that is effective against both viruses.
The second major change is that after a very exhaustive search of hundreds of medical journals and articles, I have concluded that HIV is not the primary cause of AIDS but remains an important co-factor. This will come as a shock to many of you as I have always been an HIV person. I have always believed until now that HIV was the primary cause of AIDS. For several years, the only major publication in the United States that did not believe that HIV was the primary cause of AIDS was The New York Native. For years, they have claimed that HHV-6, variant A, was the real culprit in AIDS. The New York Native is no longer alone in taking this position. Positive Health News is now the second national publication that supports this position. Neenyah Ostrom, who writes a weekly column for the Native, expressed the belief that HHV-6A was really the African Swine Fever Virus (ASFV) and was the common factor causing illness in both AIDS and Chronic Fatigue Syndrome.
For a long time, I had several questions about her theories. I read her book Americas Biggest Cover-up and was only partly convinced. I had several questions that needed to be answered. First, did a variant A strain of HHV-6 exist? Second, was it missing in the general population, but present in all persons with AIDS and CFS? Third, were long term HIV+ non-progressors absent the virus - HHV-6A? Fourth, did tests confirm that this virus was present in all HIV+ persons who progressed to full blown AIDS? Sixth, did HHV-6A have the same genome and characteristics of the African Swine Fever Virus? After 4 weeks of exhaustive research, I have found, documented and published in this newsletter 10 characteristics of the African Swine Fever Virus (ASFV) that it has in common with HHV-6A. This information, that documents that HHV-6A is African Swine Fever Virus, is appearing in print for the first time. In addition to this, there is also published 10 symptoms that AIDS in humans has in common with ASFV in swine. This makes a total of 20 common factors linking AIDS and HHV-6A to African Swine Fever. Even more stunning is information linking the start of the world AIDS epidemic to this strain of African Swine Fever Virus to US Biowarfare labs, Cuba and the CIA. The documentation I have published herein is overwhelming. Anyone who wants to challenge the facts I have presented supporting this theory will have a lot of work cut out for them. They must first prove that there are differences between the two viruses. My own search, which I started without any preconceived opinions as to the outcome , has been unable to find any differences between the two viruses. All the evidence now available indicates that of the two viruses, HIV and HHV-6A, the most destructive by far is HHV-6A which has all the characteristics of African Swine Fever virus.
JOHN BASTYR UNIVERSITY SURVEY. The Bastyr University will pay you to fill out a questionnaire if you are using nutritional or alternative therapies in the treatment of AIDS. For more information, call Cherie or Maggie at 800-475-0135. Positive Health News, Report No. 10 Copyright, January, 1996 by Keep Hope Alive. All Rights Reserved. Excerpts may be quoted from this publication provided the publisher, Keep Hope Alive, name and address are included and credited as the source of the information. For permission to make more extensive reprints, contact Keep Hope Alive.
In the last week of December, 1995, Milwaukee AIDS Project sent its clients, along with the Client Newsletter, a reprint of Dr. Bihari's Press Release on Naltrexone. Since Jan 1st, MAP case managers have reported receiving hundreds of phone calls from clients wanting more information on Naltrexone with many indicating they want to start using it. Already, physicians throughout Wisconsin are prescribing Naltrexone to MAP clients with HIV/AIDS. MAP is part of ARCW, the AIDS Resource Center of Wisconsin, and is not funded by pharmaceutical money. A monthly column on alternative AIDS therapies, beginning in Jan. ,1996, is being published in MAPs Client Newsletter. The column is written by Jim Prentice, who featured an article on Naltrexone in the Jan., 1996, Client Newsletter.
The following interview with Dr. Bernard Bihari of New York City took place on Nov. 10, 1995. Dr. Bihari's Press Release was published in Positive Health News, Report No 9, in Sept., 1995. Dr. Bihari recommended Naltrexone in 3 mg capsules to be taken once a day before bedtime as a treatment to stop AIDS progression. Some of his patients have been on Naltrexone for as long as 8 years with no decline in immune function. This interview should answer a number of frequently asked questions about the immune modulator - Naltrexone.
Mark: What is Naltrexone doing for persons with AIDS over a long period of time?
Bihari: I have a large number of patients who have been on Naltrexone for the past 4 or 5 years with CD4 counts that fluctuate and yet are as high now as when they started on Naltrexone. I have patients that have been using Naltrexone for as long as 7 years with no decline in immune function and virtually no drop in CD4 levels. I have several patients with very low T cells counts, less than 10, who feel healthy enough to hold full time jobs and have done so for several years. I am not seeing the types or frequency of opportunistic infections that would usually be expected of someone with full blown AIDS.
Mark: How does Naltrexone work?
Bihari: Naltrexone stimulates the production of the endorphins, beta and Metenkephalin. In a lab, when endorphins are added to cell cultures, macrophage activity is significantly stimulated as is CD4 and CD8 activity. I have found that CD8 cells increase when infections occur and this helps them fight the infections. When I studied the endorphin Metenkephalin in a controlled study on 20 people, it tripled the Natural Killer Cells. In the body, endorphins are produced by the adrenal glands. However, people with AIDS, cancer and other immune related diseases have low endorphin production.
Mark: Is there a connection between exercise and endorphin production?
Bihari: Aerobic exercise increases both types of endorphins.
Mark: In your Press Release of Feb., 1995, you stated that three patients became PCR negative. Are any more of your patients PCR negative for HIV?
Bihari: I have tested over 70 of my patients by PCR. Presently, I have 7 patients whose test results by PCR are not measurable, meaning the viral plate count is below 10. The virus may be there, but it is in too small a quantity to be measured by PCR. These 7 patients have used Naltrexone for 2 years or longer. Recently, I tested new 6 patients, who started on Naltrexone, every 90 days for 6 months and they had an average 80% decrease in HIV viral load as measured by PCR. However, this is a very small number and I wouldnt want to hang my hat on it - scientifically. What is interesting is that the acid interferon levels also drop, but very gradually. It takes about 6 months for a significant drop in interferon levels to occur.
Mark: How many of your patients are using AZT, DDI, D4T, DDC and other nucleoside analogs along with Naltrexone?
Bihari: Very few, almost none.
Mark: Some people have said Naltrexone is the same thing as Antabuse, a drug used for the treatment of alcoholism. Is this true?
Bihari: No, it is not. Antabuse and Naltrexone are completely different. Antabuse makes people who drink alcohol feel very sick. Naltrexone in a 3 mg dose has no side effects when alcohol is consumed. However, Naltrexone interferes with narcotic pain killers like Morphine or Codeine and other similar drugs. If narcotic pain killers are used along with Naltrexone, they wont work as Naltrexone interferes with their activity.
Mark: Does Naltrexone decrease Cortisol and Tumor Necrosis Factor(TNF) levels like it lowers acid labile alpha interferon levels?
Bihari: I have not tested for TNF levels. However, the same gene is responsible for making acid interferon as for making TNF. In theory, what lowers acid interferon should also lower TNF levels.
Mark: Does Naltrexone have any effect on Lymphoma?
Bihari: I have had about 1 case out of 100 who develop lymphoma every year. The average is about 4 out of 100. I used Naltrexone on a patient HIV- who had lymphoma. She had 3 golf size lymph nodes in her groin. She took Naltrexone in 3 mg dose and in 3 months, the lymphoma completely disappeared.
Mark: What about Naltrexone for cancer?
Bihari: I used Naltrexone on 3 patients with pancreatic cancer. In 3 or 4 months, the pain and jaundice disappeared and they went back to work. One of the patients has remained stable for the past 4 years and continues to take the Naltrexone. Ive also used Naltrexone on patients with colon cancer and non-Hodgkins lymphoma. One HIV+ patient with lymphoma was successfully treated with a combination of chemotherapy and Naltrexone.
Mark: What effect does Naltrexone have on fatigue, poor appetite and insomnia?
Bihari: Usually fatigue and poor appetite are caused not by HIV, but some opportunistic infection. When you treat the infection, the fatigue disappears and appetite returns.
Mark: What effect has Naltrexone had on swollen lymph nodes?
Bihari; There is a gradual reduction in swollen lymph nodes after 2 or 3 months, although they dont completely disappear.
Mark: What about KS?
Bihari: Most of my patients with KS had it when they came to me. However, I have had a few develop KS, 5 or 6, after being on Naltrexone.
Mark: Was the KS benign or aggressive?
Bihari: Only in one case was it aggressive. In the others it was benign.
Mark: In stabilizing CD4 counts, was there any difference in PWAs with high CD4 counts versus low?
Bihari: In persons with over 300 CD4 cells, Naltrexone is 95% effective in stopping CD4 decline. In persons with CD4 counts between 200 and 300, it is 85% effective and in persons under 100, it is about 60% effective in stopping CD4 count decline. This does not mean that Naltrexone is not doing them any good because their CD4 counts drop.
Mark: Could the higher percentage of patients with low CD4 count continue to drop because of the immuno-suppressive effects of drugs used as prophylasis to prevent PCP and other infections?
Bihari: I dont know. I am not aware of alternatives to the current drugs being used as a prophylasis. I use drugs as prophylasis to prevent PCP because they are effective.
Mark: Have you found any drugs to prevent PCP that do not have the side effects of Bactrim, Septra or Dapsone?
Bihari: Recently I learned about Mepron (Burroughs Welcome). It has few side effects when used in a moderate dose but is very expensive. It was originally developed to treat malaria but was found to be effective for treating PCP.
Mark: Does Naltrexone reduce the incidence of CMV Retinitis?
Bihari: I have almost no cases of CMV. I have had one case of CMV in 5 years. From the number of patients I have had, I should have had 100 cases. In persons with CD4 counts below 150, I place them on Acyclovir to prevent CMV. The dose I usually prescribe is 800 mg 6 times a day.
Mark: I know of one person who took much higher doses of Acyclovir and developed CMV Retinitis. However, they were not on Naltrexone.
Bihari: All my patients who take Acyclovir are on Naltrexone.
Mark: It looks like the combination therapy is more effective than using Acyclovir alone. Are there any side effects to using Acyclovir?
Bihari: Astoundingly, none, with the exception of one patient who gets fatigue if he takes over 1600 mg daily.
Mark: What other drugs do you use that have few side effects?
Bihari: Diflucan is effective to prevent and treat thrush and cryptococcal meningitis. There are no side effects. I have had patients on Diflucan, 100 mg daily, Acyclovir and Naltrexone continuously, for several years. I have several patients on these combinations who have CD4 counts below 10 and have been going to work for the past several years. I have one patient who came to me with 4 CD4 cells 4 years ago and he still feels well enough to continue working a full time job. He still has 4 CD4 cells. However, he has more of other immune cells that are very important in AIDS, mainly the Natural Killer cells and macrophages.
Mark: Is Naltrexone the chemical name or the brand name?
Bihari: Naltrexone is the chemical name. Dupont sells it under the brand name Revia.
Mark: Where do pharmacies get Naltrexone?
Bihari: Any pharmacy can order it from Dupont. Dupont has renamed Naltrexone Revia. The old name was Trexon. The tablets come 50 mg each. The pharmacy has to grind the capsules and fill them in 3 mg capsules as the patient takes just one 3 mg capsule daily. Two 50 mg capsules makes a months supply. Some pharmacies wont bother to do this for one patient as they wont make money on it, since they have to buy a bottle of 50 mg tablets which costs over $200.00. Prescriptions can be filled through Bigelow Pharmacy in New York City. The cost is $24.00 for 30 capsules, a months supply.
Note: Dr. Bernard Bihari can be reached in New York City at 212-929-4196 Fax 212-229-9371.
Bigelow Pharmacy, 414 6th Ave, New York, NY 10011. 212-533-2700. They compound it in 3 mg capsules. Current cost is $24.00 for 30 capsules. $48.00 for 60 and $72.00 for 90. Add $3.00 per order for postage and include your prescription. Also, your physician can phone in an order and you can place it on a credit card.
A second source that will compound Naltrexone in 3 mg. capsules is Apothecure Pharmacy in Dallas, TX 800-969-6601. Local pharmacies may prefer to compound it in a solution. Bihari prefers the capsules as the product remains more stable. If you use a liquid, keep it refrigerated and do not order more than a one months supply at a time.
It might be more suitable to use Naltrexone dissolved in a liquid for children with AIDS. The dose should be 1 mg per day per 50 lbs of body weight. A child weighing 25 lbs would receive 1/2 mg daily whereas a child weighing 100 lbs. would use 2 mg daily. Bigelow can compound Naltrexone in any dose prescribed in capsules or place it in a liquid medium. In a liquid, 3 mg per 3 ML would make it easy to measure when smaller doses are needed. Always keep the liquid Naltrexone in a refrigerator when not in use. Do not order more than a one months supply at a time to maintain potency.
First, show your Physician a copy of this article and ask him for a prescription. If your Physician is not convinced and you still want a prescription for Naltrexone, you may phone Dr. Bihari at 212-929-4196 for a telephone conference to receive a prescription for Naltrexone. You may also call Dr. John Pittman MD (Raleigh, NC) for a prescription for Naltrexone in conjunction with a telephone consultation, providing that is all that is needed. His phone number is 800-473-9812 or 800-539-9812.. Dr. Pittman is now prescribing Naltrexone to all his HIV+ patients. There is a fee for the tele-conference consultation.
Also note that many Infectious Disease (I.D.) Physicians will try to convince you to use a nucleoside along with Naltrexone. However, the success of Naltrexone has been that of a monotherapy, not a combination therapy with a nucleoside. Nucleosides are not effective against either of the two AIDS viruses in the lymph system and do not have the intelligence of the NK cells to search and destroy other cells infected with the virus.
The purpose of this chapter is to show evidence that it takes two viruses to cause AIDS, not one virus, HIV, as has been long believed. The interaction between HIV and HHV-6A (African Swine Fever) is this: If you are infected with both viruses, you are a candidate to develop AIDS. If you have HIV alone, you will likely be a long term non-progressor. If you have HHV-6A alone, you may develop Chronic Fatigue Syndrome (CFS) which can be very debilitating. According to Dr. Patricia Salvato MD, the most common symptoms of CFS patients are Lymphadenopathy, low grade fevers and fatigue. Other symptoms include thrush and yeast infections. The third cause of AIDS are many of the current medications currently used to treat these conditions. Many of these drugs are themselves immuno-suppressive and lower white blood cell counts.
Terms and Definitions: Human Herpesvirus 6 is HHV-6. There are two groups of variants, A and B. For purposes of this article, the following expressions all refer to the same virus: HHV-6, variant A, (HHV-6A) is (U1102 and GS isolates) is Human B Cell Lymphotropic Virus (HBLV is African Swine Fever Virus (ASFV).
Variant B, is a mild herpes virus that causes minor symptoms in children with no long lasting side effects. Variant B is widely disseminated through the population and does not depress the immune system. Disease Model. ASFV (HHV-6A) is the primary virus that causes AIDS and does most of the damage to the immune system. HIV is a co-factor in AIDS progression. ASFV without HIV causes Chronic Fatigue Syndrome. HIV without ASFV does little or no damage to the immune system.
On Dec. 7th, 1995, ABC News carried a nationwide televised broadcast on another virus that may be the cause of AIDS - HHV-6. Robert Gallo was quoted as saying that: When you compare the two viruses (HIV and HHV-6), in a laboratory, the more destructive by far is HHV-6. Peter Jennings said he had heard something about variant strains of the virus, but Gallo avoided answering him directly and repeated his reference to HHV-6, without indicating that variant A is the co-factor in AIDS. Robert Gallo knows more than he is saying publicly. Several researchers have published articles in medical journals that identified variant A as the virulent HHV-6 co-factor in AIDS.
In the ABC News interview, Virologist Konstance Knox, who works at the Medical College of Wisconsin, described the effects of HHV-6 infection in people: It can kill people. It can cause fatal brain disease. It can cause fatal bone marrow destruction. It can cause fatal lung infection. ABC News news reporter McKenzie told viewers that researchers now believe that HHV-6 works together with HIV, by attacking the immune system, unleashes the HHV-6 to ravage the body.
The first letter linking AIDS to African Swine Fever Virus (ASFV) was published in The Lancet, Apr. 23, 1983, by Jane Teas of the Harvard School of Public Health, Boston MA. Jane Teas and her colleague, John Beldekas, of the Boston University School of Medicine, found that the symptoms of ASFV in swine (pigs) was almost identical to symptomology found in AIDS patients. Common symptoms of both diseases are: fevers, swollen lymph nodes, pneumonia, skin lesions (like KS) and wasting syndrome. In pigs, ASFV is usually fatal, often within two weeks of the onset of symptoms, although there are some swine that survive ASFV infection. Letters linking AIDS to ASFV also appeared in The Lancet (June 11, 1983) by St. John RK and a letter by Jane Teas in Ann NY Acad. Sci, 1984;437:270-2. Another on African Swine Fever and AIDS in The Lancet, on Mar 8, 1986 by Beldekas and Teas.
From 1983 to 1986, Jane Teas (Dept. of Pathology, Human Ecology Assn., Boston), John Beldekas (Boston University Medical School) and James R Hebert (Dept. of Epidemiology, Am Health Fdn, NY) searched for evidence of the ASF virus in AIDS patients. An article on their findings was published in The Lancet on March 8, 1986. What they found was the presence of ASFV in the blood of 9 of 21 AIDS patients using haemadsorption tests and found ASFV in 10 AIDS patients using immunofluorescence tests. Sixteen controls were used in the tests and one tested positive for ASFV. Beldekas also noted giant cell formations, a characteristic of ASFV in swine cell cultures. Beldekas indicated that possibly a new variant strain of ASFV was an infectious agent in AIDS and would cross react with Lisbon 60 strain which is known to cross react with all other strains of ASFV. African Swine Fever Virus is not supposed to infect people. What was ASFV doing in the blood of 9 AIDS patients and why was it not found in all 21?
What may have been happening in the 12 AIDS patients who did not test positive for ASFV in the blood was that the virus may have been replicating in the cells. This will never be known since DNA amplification by PCR was not used in the test. The same problem occurs when testing for HHV-6A. In HHV-6A, it sometimes requires PCR tests to find the virus. A person infected with HHV-6A or ASFV who does not test positive for the presence of antibodies may show the presence of the virus by DNA amplification through PCR. Dr. Patricia Salvato MD (Houston, TX) found 98% of her patients with full blown AIDS to have HHV-6A by PCR amplification. This does not mean the other 2% were not also infected with the HHV-6A as the blood sample may not have had the presence of the virus that was elsewhere in the patient (i.e. lymph system). Antibody tests are less reliable than PCR. It is well known that some persons test negative for HIV antibody who are actually infected with HIV.
In August, 1986, John Beldekas was invited to go to the NCI and present his findings on the link between ASFV and AIDS, which he did. Beldekas gave samples of all his lab work to Gallo. Later, the government asked Beldekas to turn over all his reagents and lab work to the government, which he did. Beldekas had found ASFV presence in nine of 21 AIDS patients using two standard procedures. At the meeting, Gallo was reported saying: we know it is not ASFV. How could Gallo know this as he hadnt done any of his own tests to look for ASFV?
Two months later, Gallo published an article in Science (Oct 31, 1986) that he discovered a new possible co-factor in AIDS, a virus he called Human B Cell Lymphotropic Virus which he named HBLV. Like ASFV, HBLV infected B cells and also lived in macrophages. Did Gallo steal Beldekass ASF virus he found in AIDS patients and rename it HBLV? Later on, when Gallo found that HBLV could also infect other immune cells, he changed the name of HBLV to HHV-6. Eventually, Gallo identified his HBLV as the variant A strain of HHV-6 and called it a human herpesvirus.
THE MERCK VETERINARY MANUAL is the definitive publication used by veterinarians for information on animal diseases. It can be found in most public libraries. Here it part of what it says about African Swine Fever virus in hogs.
The first sign is fever...There is early leukopenia (low white blood cells). The animals usually stop eating and become listless, uncoordinated and cyanotic....Vomiting, diarrhea and eye discharges are sometimes observed. Gross lesions...include hemorrhages of lymph nodes...and congestive splenomegaly...Hairless portions exhibit edematous areas of cyanosis (swollen purple lesions)...Pleural, pericardial and peritoneal fluids are excessive...severe edema of the lungs and walls of the gall bladder....virus usually replicates in macrophages in tonsils and regional lymph nodes.
What Mercks is saying is plain English is that ASFV symptoms include fevers, low white blood cells, fluids in the lungs (pneumonia?), swollen lymph nodes, diarrhea, swollen veins that are purple (Kaposis sarcoma?), congested spleens and a kind of dementia (listless and uncoordinated). These symptoms are also found in AIDS in varying degrees. John Beldekas writing in The Lancet, March 8, 1986 stated: Both AIDS and chronic ASFV are characterized by fever, hyperplastic lymph nodes, skin lesions, hypergammaglobulinaemia, immune-mediated pneumonia, thrombocytopenia, encephalopathy, high titre non-neutralizing antibody production, and lymphocyte depression. Beldekas identified nine symptoms common to both viral infections.
Mercks Manual also says the ASF virus is killed at 56 degrees Centigrade. An article appearing in The Lancet, Jan 26, 1985, by Montagnier, Spire, Dormat and Cherman was titled Inactivation of Lymphadenopathy-associated virus by heat said that Lymphadenopathy associated virus (in AIDS) is inactivated by heating at 56 degrees C for 30 minutes. Since other researchers found that the HIV virus is inactivated at 60 degrees C and not 56, and it is known that HHV-6A is active in the lymph nodes (Gallo, Carrigan, Knox), the virus inactivated by Montagnier must not have been HIV, but rather HHV-6A.
An article by DA Gregg et al appearing in J. Vet Diagn Invest., Jan. 1995, makes the observation that in African Swine Fever (ASF), the interdigitating dendritic cells (IDCs) are infected and that they lose their ability to initiate an immune response. He closed by noting: Infection of IDCs (dendritic cells) has also been demonstrated in human immunodeficiency virus, and these infections have some aspects in common.
An article by A Canals et al, published in Vet Microbiol, Nov., 1992, found that in peripheral blood mononuclear cells (PBMC) from pigs infected with ASFV, there was progressive increase of the CD8 subset when the cells were stimulated with infective (ASF) virus. In AIDS patients, one of the first things noticed in blood tests was the CD4/CD8 inversions. In healthy humans, HIV-, CD4s are always higher than CD8s. In AIDS, CD8s increase and are almost always higher than the CD4s.
In Chronic Fatigue Syndrome (CFS), Dr. Patricia Salvato found 78% of her CFS infected with HHV-6. Dr. Nancy Klimas found a 19% elevation in CD8 counts in her CFS patients (1). In CFS and AIDS, African Swine Fever virus (sic:HHV-6A) increases CD8 counts, the same as it does in swine.
1. Immunologic Abnormalities in Chronic Fatigue Syndrome, by Nancy Klimas; J. of Clinical Microbiology, June, 1990.
S. Zaki Salahuddin, Robert Gallo et al state that HBLV (HHV-6A) has a lipid membrane and a diameter of the enveloped particle of about 200 nm. (1). The African Swine Fever Virus (ASFV) has been identified as having a lipid membrane and a diameter of 200 nm by J.L Carrasosa et al (2) and S.S. Breese (3).
1.Science Reports, Vol. 234, Oct 31, 1986, 597.
2.Virology, 132, 160-172
3.Virology, 28, 420-428.
An article by MJ Torres-Anjel published in Ann NY Acad Sci, Jun 16, 1992, says that The AIDS viral ecology coincided with African Swine Fever (ASF) in the Americas. Haiti became the focal point for both infections. He noted that in the wars for independence in Africa (Angola etc), there were massive movements of soldiers from the American continent to Africa and back.
In Dec., 1995, I had a discussion with a PWA from Rio Rancho, NM, who has Kaposi Sarcoma. At the time, he told me that on three occasions when he ate pork, he had a flare-up and growth in his KS lesions. He did not get this effect from beef, turkey or chicken. He said: when I eat pork, the KS goes wild. He was not aware that research by Gallo and others have found the presence of HHV-6A in KS lesions. Since the ASF virus is known to systemicly infect pigs, it would not be surprising that eating pork would provide chow for ASFV(HHV-6A) in humans and adds more evidence that ASFV and HHV-6A are one and the same virus. This virus likes pork.
Gallo, Carrigan, Knox and other researchers have identified HHV-6A as a DNA lymphotropic virus that can infect T cells, B cells and monocytes and is systemicly infective and is found in most organs of persons with full blown AIDS. The Merck Veterinary Manual says this about ASFV: This DNA virus replicates primarily in cells of the monocyte-macrophage system and is found in nearly all fluids and tissues of acutely infected pigs. The fact that both viruses are DNA types and have tropism for infecting immune cells and can cause systemic infections adds further proof that both viruses are one and the same.
Both ASFV and HHV-6A are hemorrhagic (cause bleeding) (1) and the immune reaction to ASFV in pigs shows an absence of effective neutralizing antibodies. (2). Since Dr. Salvato found 98% of her patients with full blown AIDS had replication of HHV-6A in the cells, as determined by PCR. This is comparable evidence of an absence of effective neutralizing antibodies. Both ASFV and HHV-6 are Icosahedral viruses (3, 4) and both are envelope viruses (5, 6). Also, both viruses, ASFV and HHV-6A, mature in the cytoplasm (4, 5). The replication of ASFV and HHV-6 (A) is inhibited by Phosphonoacetic acid. (6, 7). The replication of both viruses is also inhibited by Phosphoformic acid (Foscarnet) (6, 8).
1. Neenyah Ostrom, The New York Native, Oct 10, 1994.
2. Mercks Veterinary Manual.
3. R. Gallo et al, Science Reports, Oct 31, 1986 (601)
4. Carlos Martins and M. Lawman in a Letter to The Lancet, June 28, 1986 (1504).
5. P Biberfeld et al, J. Natl Cancer Inst, 1987, Nov; 79(5):933-41.
6. DV Ablashi et al, In Vivo, May-Jun, 1991; 5 (3):193-9
7. M.A. Moreno et al, J. gen. Virol, 93, 252-258.
8. John Beldekas et al, The Lancet, March 8, 1986, 565.
In his letter to AIDS Res Hum Retroviruses of Oct. 4, 1988, Josephs, of the National Institute of Health (NIH) and an associate of R. Gallo, said that HBLV is not African Swine Fever Virus and said that HBLV (HHV-6A) matures in the nucleus of the cell whereas ASFV matures in the cytoplasm. He is correct in saying that ASFV matures in the cytoplasm (1). However, P Biberfeld found unenveloped nucleocapsids of HBLV (HHV-6A) in the cytoplasm.(2). Josephs offered no clinical evidence in his letter that HBLV (HHV-6A) matured in the nucleus of cells (3).
1. Carlos Martins and M. Lawman in a Letter to The Lancet, June 28, 1986 (1504).
2. P Biberfeld et al, J. Natl Cancer Inst, 1987, Nov; 79(5):933-41.
3. S.F. Josephs et al in a Letter to AIDS Res Hum Retroviruses, Oct 4, 1988(5):317-8.
So far, in this article, I have listed a total of 20 factors that ASFV and HHV-6A have in common. Ten are common areas of symptomology and 10 are particular characteristics of the virus. What is just as significant is the absence of clinical evidence that shows a difference between the two viruses. The only real test to settle the issue is for researchers to attempt to infect a pig with blood from an AIDS patients with Lymphadenopathy and see if it brings on African Swine Fever. If the real virus that causes AIDS came from pigs, then infecting them with the AIDS virus (HHV-6A) should cause them to develop ASFV. If it does, it will be case closed. Are there any researchers reading this article that are willing to do an in-vivo test on live swine? America's Biggest Cover-up
A book came out late in Nov., 1993, titled America's Biggest Cover-up, by Neenyah Ostrom. It alleges that HHV-6 (A) may be the primary causative factor in both AIDS and Chronic Fatigue Syndrome. There are two strains of HHV-6, variants A and B. HHV-6 (Variant B) is a common herpes virus and is not a life threatening infection. Ostrom, a prolific researcher and writer, has written articles for The New York Native on HHV-6 and other AIDS related topics for several years (1). Ostrom says the variant A strain of HHV-6 is the culprit in both CFS and in AIDS. Ostrom has interviewed most of the major researchers in the field, as well as countless patients and government officials. She has found many similarities between Chronic Fatigue Syndrome and AIDS and believes that they are part of the same epidemic. She argues that until their connection is admitted by top government researchers, there is little hope that real progress will be made in stopping these two expressions of the same syndrome. Ostrom also says in her book that HHV-6A is really the African Swine Fever virus (ASF). Ostrom reports that CFS patients have lost much of their B cell and natural killer (NK) cell protection and both groups are susceptible to night sweats and many forms of cancer, lymphomas and TB. The book is available at your local bookstore.
1. New York Native, PO Box 1475, NY, NY 10008
This report by S.S. Froland (1) of the Dept. of Immunology, Oslo, Norway, was about a family of three - father, mother and daughter who all died from immune dysfunction in 1976 from classic AIDS symptoms which included Lymphadenopathy, lymphocyte depletion, CMV, weight loss, pneumonia, dementia and other neurological manifestations and candidiasis.
The father, who was a sailor, had made ports of call in Africa in the early 1960s. The symptoms of Lymphadenopathy and upper respiratory infections first appeared in 1966. His medical records showed that, during this period when he visited African ports, he had contracted sexually transmitted diseases twice. (1) An autopsy showed the presence of multinucleated giant cells in the lymph nodes.
Unlike other reported AIDS cases before 1979, frozen blood serum from all three patients had been kept since 1971. When the blood serum was analyzed, all three patients tested positive for HIV-1 antibody by immunoassays with confirmation by Western Blot. The sera tested negative for HIV-2 (1). This is the first confirmed case of AIDS with an origin linked to Africa that occurred in the 1960s.
Did the virus that infected the Norwegian family originate from African pigs that was transmitted to people? Viruses from swine have done this before. In 1919, there was a world wide epidemic known as The Swine Flu. Over one million people died from pneumonia related to this flu. Humans have an affinity to pick up viruses that start in swine and vice versa. One PWA told me that the Italian community was not affected by the swine flu of 1919 and credits this to the amount of garlic consumed daily by Italians. The AIDS virus or viruses (possible HIV also?) that started in African swine in the 1960s could not have been virulent (easily transmitted) between people or the epidemic would have started sooner than it did.
1. S.S. Froland et al, The Lancet, June 11, 1988 (1344-45)
It is no secret that the U.S. as well as foreign governments have been involved in research on germ and biological warfare agents for many years. Part of biowarfare research is to culture viruses so they become more deadly and contagious. It has been reported that Eduardo Perez, a Cuban national, who was on trial in a New York Federal District Court testified on Sept. 10, 1984, that in 1980, as part of a CIA biological warfare scheme against the Castro Cuban economy, a ship traveled from Florida to Cuba with germs.
Drew Fetherston and John Cummings, wrote a story linking ASF to anti-Castro operatives, that was published in Newsday, Jan. 9, 1977. Fetherson and Cummings interviewed Cuban exiles and intelligence sources for several months. Their primary U.S. intelligence source said he had been given a container with ASFV1 at Fort Gulick, in the Panama Canal Zone. (1) From Panama, the container with ASFV was taken to a place in Cuba, near Guantanamo around March, 1971. The outbreak of ASF in Cuban pigs became known to have occurred two months later, in May, 1971, causing the Castro regime to order the destruction of 500,000 pigs. Pork is the second largest industry in Cuba after sugar cane. Syndicated columnist Jack Anderson wrote several articles on sources he contacted that indicated that the CIA had engaged in biowarfare against Castros swine industry and that Castros allegations that the CIA had planted the ASFV virus in Cuba were correct.
Once released in Cuba, ASFV (HHV-6A) may have been brought back to the United States by Cuban refugees and the ASF virus could have been enjoined with the already benign HIV virus making a lethal combination that started the AIDS epidemic. For the record, the CIA has denied having developed and released the ASF virus in Cuba. However, the secretive nature of their sometimes clandestine activities often requires the release of disinformation as well as withholding information for national security reasons. Translation: it is OK for them to lie to the public to avoid embarrassment.
My own version of a possible scenario as to what happened is that the ASF virus was taken from Africa to US labs as part of their biowarfare research program. The CIA may have taken the most virulent strains of ASFV, which existed in Uganda. The Ugandan strain is known to destroy cells and is more aggressive than the Portuguese strain(1). The ASF virus may have been cultured to make it more virulent and contagious. to more effectively destroy Castros second biggest industry - pigs. The CIA released the enhanced ASF virus in Cuba in an attempt to create economic hardship and destabilize the communist government. However, the enhanced ASF virus had an unexpected side effect. It could more easily jump species and infect humans as well as pigs.
When you consider the Norwegian family that died of AIDS in 1976 with symptomology starting in 1966, it indicates that AIDS had its origin in Africa in the 1960s, and may have been transmitted from swine to people, who could have contracted the disease by eating undercooked pork or handling raw pork with infected blood. However, this earlier AIDS virus was not easily transmittable or the AIDS epidemic would have started in the 1960s. When we learn more about the genome (genetic structure) of HHV-6A, we should be able to determine which African strain of the ASF virus the CIA used for biowarfare against Cuba.
At the time of the ASF outbreak in the pig population in Cuba, Cuban civilians eating pork infected with the ASF virus were reported getting sick(1). What was the ASF viral status of the tens of thousands of Cubans evicted by Castro during the Mariel Boatlift, which occurred after the second ASF outbreak in 1980? News reports at the time indicated many were gay, ill or prisoners. Was this Castros return gift? Did Cuban refugees bring the ASF virus to southern Florida where some gay Cuban refugees intermingled with the gay population? There is much evidence to support this as many gays took in the Cuban male exiles as roommates. Was HIV, as a benign virus, already present in some members of the gay community? Did the co-infection of ASF (HHV-6A) and HIV start the AIDS epidemic? The preponderance of evidence suggest that this is the scenario that unfolded.
Some Gays in New York City invited Cuban refugees to move in with them. Late in 1980, the first cases of GRID (Gay Related Immune Deficiency) appeared in New York City. At about the same time, Haiti had an outbreak of both African Swine Fever and AIDS (2). The Hepatitis B vaccination trials were in progress in the gay community. When an infected donors blood was used in the development of the Hepatitis B vaccine, this quickly spread the disease through major gay centers in the United States. Also, at the same time, blood products from infected donors may have ended up in small pox vaccinations given by the World Health Organization (WHO) to millions of persons in Africa. This could explain the simultaneous outbreak of AIDS on both continents. As the two viruses spread through exchange of body fluids, they spread the AIDS epidemic. However, the persons receiving only the ASFV (HHV-6A) virus, and not HIV, developed Chronic Fatigue Syndrome with Lymphadenopathy, low grade fevers and fatigue while the persons receiving only HIV without HHV-6A became long term HIV+ non-progressors with no symptoms at all. In AIDS, both viruses work synergisticly to infect immune cells, most organs and cause neurological damage. The most damaging of the two viruses is ASFV which makes it the primary cause of AIDS with HIV as a co-factor. If you can get rid of ASFV, you no longer have AIDS or chronic immune dysfunction.
This disease model explains why AZT and all the drug combinations of the past decade have been ineffective in treating AIDS. The drug combination have been directed at HIV and not at the primary cause of AIDS that Gallo calls HHV-6A and which is a variant strain of African Swine Fever.
1. AIDS INC., by Jon Rappoport, Human Energy Press, San Bruno, CA.
2. Ann NY Acad Sci, Jun 16, 1992, by MJ Torres-Anjel.
Dr. Robert Gallo has recently written an article on "Disseminated Human Herpes Virus 6 Infection in AIDS" and stated "this concept, which has gained additional ground, is primarily based on the frequent isolation of HHV-6 from AIDS patients and its ability to infect and kill CD4 T cells, and on the demonstration of several unique interactions between HHV-6 and HIV." It is also significant that Gallo has stated that HHV-6, like HIV, can infect B cells. Both Gallo and Carrigan believe that AIDS is caused by the actions of two viruses instead of one.
A growing body of scientific research by Robert Gallo, Donald Carrigan and others indicate that HHV-6(A) can infect and disrupt the function of B cells and at least one weaker subset of NK cells. According to Carrigan, HHV-6A stops B cells from maturing into plasma cells. Plasma cells produce antibodies.
Gallo found a subset of NK cells that was immune from attack by HHV-6A. This subset of NK cells was capable of destroying other immune cells infected with HHV-6A. If this subset of NK cells (CD56+?), can be sufficiently stimulated into activity, they should be able to substantially reduce the viral load of both HHV-6A (ASFV) and HIV.
1. HOW YOUR IMMUNE SYSTEM WORKS, by Jeff Baggish MD (Ziff Davis Press, Emeryville, CA))
In Dec., 1995, I ran a computer search for HHV-6 on AIDSLINE at the National Library of Medicine and retrieved several articles. One abstract by P Lusso et al (Int. AIDS Conf, Jun 1991) showed why HIV is more dangerous in the presence of ASFV. ASFV causes many more immune cells, besides the CD4 cell, to present the CD4 receptor on their membrane which makes the other immune cells also subject to infection by HIV. Like HIV, ASFV also uses the same CD4 receptor to invade immune cells. The immune cells with the CD4 receptor may be invaded by both HIV and ASFV (HHV-6A) at the same time.
Of HIV in the presence of HHV-6A, Lusso wrote: Since CD4 is the receptor for HIV-1, HHV-6 may thus broaden the cellular host-range of HIV-1, favoring its spread in co-infected patients. What Lusso is saying that HIV in the presence of HHV-6 is invasive of many more immune cells than without HHV-6.
Several authors, including Gallo, have published scientific reports that did not specify if the HHV-6 virus they were referring to was strain variant A or B. This has caused some confusion in the scientific community. However, several scientific journals where articles were published have identified HHV-6(A) as being either of the following isolates: U1102 or GS. GS stands for the initials of a PWA from whom the virus was isolated. One Abstract cited U1102 as a HHV-6, variant A, isolate from a Ugandan AIDS patient. References to U1102 as being HHV-6A have been published in the following medical journals:
1. J. Virol. 1995, Aug; by Araujo JC et al
2. Virology, 1995, May; by UA Gompels et al
3. J. Virol Methods., 1995, Feb.; by L Foa-Tomasi et al
4. J. Immunology, 1994, Jun.; by M Furukawa et al
5. Virology, 1994, May; by F Kashanchi et al
6. Oncogene, 1994, Apr; by J. Thompson et al
7.J. Virol. 1993, Aug; by B Pfeffer at al
8. J. Med. Virol, 1992, Aug; by B Chandran et al
9. Int. AIDS Conf, 1994. by K Yamanishi et al.
An article appearing in Virology, May 15, 1994, by F. Kashanchi says that (HHV-6) strain A transformed rodent cells and transactivated the HIV-1 LTR 10 to 15 fold in both monkeys fibroblasts and human T-lymphocytes. The abstract concluded by saying that the data presented suggest that HHV-6 could have a co-factor role in the progression of AIDS. The mechanism of how HHV-6A increases HIV replication is already known from other research by Gallo. HHV-6A causes many more immune cells to present the CD4 receptor, which is what both HIV and HHV-6A use to infect immune cells.
According to Donald Carrigan, HHV-6A makes HIV up to 100 times more virulent and invasive of immune cells and does widespread damage to the lymphoid tissue where antigen presenting cells are produced. Without the dendritic antigen presenting cells, said Carrigan, the CD4s dont know what to do. Carrigan cites HHV-6A as the primary cause of swollen lymph nodes in AIDS patients. Carrigan said he spoke recently with a person HIV+ for 11 years who never had any symptoms and has a totally normal T cell count and blood profile. This person has never used any drugs or alternative treatments of any kind. He said: HIV without HHV-6A may be a benign virus. He indicated he was interested is testing blood samples from long term HIV+ non-progressors to see if they are missing the suspected co-factor - HHV-6A.
An article was published in Invest. Ophthalmol. Vis. Science, 36:2040, 1995 by Qavi, Hamida, Green, Lewis, Hollinger, Pearson and Ablashi on HIV-1 and HHV-6 Antigens and Transcripts in Retinas of Patients with AIDS in the absence of Cytomegalovirus. The article was reviewed by Neenyah Ostrom in the New York Native in Oct., 1995. Ostrom writes: Powerful evidence has just been published suggesting that Human Herpes Virus 6 (HHV-6) may be a frequent cause of vision loss suffered by more than half of all AIDS patients. Although most eye disease has been attributed to Cytomegalovirus (CMV) infection, it now appears that, along with the identification of HHV-6 as the most common infection found in AIDS patients, HHV-6 may in addition be causing a significant percentage of the AIDS Retinitis formerly blamed on CMV.
It should be noted that HHV-6A shares more in common with CMV than with variant B, which is a common herpes virus. (1) The genome of HHV-6A has only 21% similarity with the Variant B common herpes virus, but has 67% similarity with the CMV virus (3). Acyclovir, which is used to treat the common herpes virus (HHV-6B), is not effective against variant A. (2). Other research has shown that antibodies to HHV-6(B) are not effective against variant A (ASFV).(4).
1. J. Virol, 1991, Oct. by SF Josephs et al .
2. In Vivo, May-Jun, 1991, by DV Ablashi et al.
3. Virology, 1995, May, by UA Gompels et al.
4. J. Virol Methods, 1995, Feb, by L Foa-Tomasi et al
Neenyah Ostrom, writing in The New York Native, June 15, 1992 stated: [ASFV also strongly resembles CMV, according to retired USDA Plum Island Animal Disease Laboratory ASFV researcher William Hiss. In a 1971 textbook, African Swine Fever Virus, Hess pointed out that ...Herpes simplex virus and ...human Cytomegalovirus have morphological appearances similar to ASF virus when seen in thin sections. In other words, when tissue infected with ASFV are examined under the microscope, the ASFV looks like human herpes virus.]
Gallo has named the co-factor in AIDS patients as Human HerpesVirus 6 or HHV-6. However, I think Gallo knows more than he is willing to discuss publicly. The US Government does not want the rest of the world blaming us for contributing to the start of the AIDS epidemic. You can be certain that for national security reasons the CIA will always deny that its biowarfare department cultured a strain of the ASF virus to make it more damaging and destructive to Cubas pork industry. However, the CIA could not possibly have known in advance the world-wide implications of AIDS that would result when they released this virus in Cuba and it began to infect humans.
Carrigan cited one case of a 2 yr. old child who died from HHV-6A from infections due to severe immune dysfunction. Carrigan said that under certain conditions, HHV-6A may cause AIDS without HIV. The child did not have HIV but was diagnosed as having died from AIDS. The article will be published in the Journal of AIDS in March, 1996. Carrigan said that both HIV and HHV-6A are being sexually transmitted together. Carrigan also said that in infants, those who receive both HIV and HHV-6A from the mother progress to full blown AIDS quickly while the children who are HIV+ without HHV-6A are living as long term non-progressors.
In my discussion with Donald Carrigan (12/18/95), he said that cytotoxic Killer T cells (A type of CD8 cell) can kill cells infected with HHV-6A if there are a sufficient number of CD4 cells and Antigen Presenting Cells available. The Antigen Presenting Dendritic cells, also known as CD35, are produced in the lymph nodes. However, if the CD4s and Antigen Presenting cells are insufficient, as may happen when CD4 counts are very low or serious damage has been done to the lymph nodes, then the Killer T cells do not know what to do and would not be effective in lowering the HIV and HHV-6A viral load. This brings us to the immune cells of last resort - the Natural Killer (NK) cells. They are the most active immune cells that do not require help from any other immune cell to carry out their function of destroying cells infected with viruses. Carrigan agreed with me that if the subsets of NK cells that are resistant to HIV and HHV-6A infection could be sufficiently activated, they could bring both HIV and HHV-6A under control by destroying cells infected with either or both of these viruses. Some subsets of NK cells and CD8s can be infected with HHV-6A. However other subsets are resistant to these viruses.
Note: In lab tests, NK cells are listed as the following subsets: CD56+; CD16+ and CD3-. Total absolute NK cell counts for all subsets range from 40 to 380 cells per cubic millimeter (UL) of blood. The mean average is 210 cells/UL. 210 or higher is the total number of NK cells for which we should strive to restore normal NK function. If normal NK activity can be combined with CD8s of 800 or higher, an AIDS patient will have a functional immune system, with few opportunistic infections, even if the CD4 count in the blood is zero. Zero CD4 blood counts does not mean all CD4 cells are gone as many are in the lymph nodes, where the battle is ongoing.
An article by A Canals (1) discusses an in-vivo test where ASFV was inactivated by UV light. Although, he did not say what wavelength was used. (UVA, with a longer wavelength, inactivates viruses and other pathogens. Some research in cell cultures suggest that UVB may activate HIV replication.) Canals found that active ASFV caused an increase in CD8+ subsets when added to cell cultures of blood cells whereas ASFV inactivated by UV light caused an increase in both CD4+ and CD8+ subsets.
This article raises the possibility that blood taken from a patient infected with HHV-6A and exposed to UV light (UVA1, 340 to 400 nm)) and then later reinfused into the patient might stimulate neutralizing antibodies and increases in CD4 and CD8 subsets, which would be a positive gain in immunity for the patient. Would tanning in a salon with UVA also have some benefits in increasing CD4 and CD8 subsets? Would it kill some HIV and HHV-6A in the capillaries and cells near the surface of the skin?. Tanning salons usually have both types of beds available - UVB or UVA. In cell cultures, UVA did not activate HIV, but UVB and UVC did cause increases in viral replication (2). However, no studies have attempted to repeat these results with UVB in-vivo ( in persons) measuring viral load by PCR. However, one study with six patients using UVB was done in Canada.
J.B. Hudson found only one person out of six, who had 42 UVB light treatments, change his P24 antigen status from negative to positive. All other immune markers (CD4, CD8 and beta-2 microglobulin levels) stayed stable in all six patients. None of the six patients on UVB light treatments had any opportunistic infections while receiving the UV treatment (5).
In one experiment, G. Miolo et al found that total inactivation of the HIV-1 (200SFU) was obtained in the presence of 1 microgram ml-1 of TMP and 20 kJ m-2 of UVA light. (3) Tmp is 8-trimethylpsoralen. In another experiment on cell cultures, MM Saucier found that heat inactivation, or UV-light treatment of viruses before assays almost completely ablates its ability to induce proliferation. (4). There is a complete lack of clinical evidence indicating increases in HIV or HHV-6A viral load, as measured by PCR, (or increases in beta-2 microglobulin levels), in AIDS patients using tanning beds or being exposed to natural sunlight. All the reports that suggest that PWAs should not tan or expose their skin to the sun is coming from lab cultures that do reflect the actual conditions that occur in people receiving UV light. The lab cultures are using a bovine serum that does not exist in people. If the researchers cannot duplicate in-vivo (with people) the same viral replication with UVB or UVC light that they are seeing in the lab, then it means the labs tests have some inherent flaws in design.
1. A. Canals et al, Vet Microbiol., 1992, Nov: 33 (1-4): 117-27.
2. L.E. Benade et al, Transfusion. Aug, 1994; 34 (8):680-4
3. G. Miolo, J Photochem Photobiol b., 1994 Dec: 26(3):241-7
4. M.M. Saucier, Symp Nonhum Primate Models AIDS, 1993, Sept 19-23, Abstract No 93. Atlanta, GA.
5. J.B. Hudson et al, Div. of Microbiology, Univ. of British Columbia, Vancouver, Canada.
There are times when nothing else will work or is not available that immuno-suppressive drugs should be used in treating an opportunistic infection. However, it is time for Physicians to stop using immunosuppressive drugs as a prophylaxis, on a continuous ongoing basis, to prevent illness. The big problem with giving antibiotics and some other drugs on a continuous basis to prevent opportunistic infections (OIs) is that the drugs may depress subsets of immune cells needed to control OIs. Where are the scientific studies to show that Bactrim and Dapsone that are used to prevent PCP are not also damaging subsets of immune cells and lowering the White Blood Cell counts? The Physicians Desk Reference says that both Bactrim and Septra can cause leukopenia (low white blood cell counts). Dapsones most serious side effect is to lower red blood cell counts (RBCs) and causes anemia(1). How can anyone ever expect to restore a functional immune system if you load the patient with immuno-suppressive drugs that lowers the white blood cells (WBCs) and leave them fatigued with low RBCs?
If I were a Physician, I would search for non-toxic alternatives to use as a prophylaxis to prevent disease. I would consider the herbal product, SEES-2000, to prevent PCP and colloidal silver to prevent other OIs. I certainly would have an ozone machine in my office and offer major autohemotherapy (adding ozone to a pint of blood removed from a patient and infusing it back into the patient). I would also offer UVA light therapy of blood as a treatment. I would not give any immuno-suppressive drug to a patient unless it was for the purpose to treating a condition that had already developed.
Drugs that should be given to PWAs are those that are known to stimulate a functional immune system, such as Neupogen (made by Amgen), which is used to rapidly increase the number of white blood cells and, Naltrexone, which increases the number of Natural Killer (NK) cells and DNCB, which increases both CD8 Killer T cells and NK cells. In contrast to injectable IL2, the use of a low dose homeopathic IL 2 such as Detoxosode for Viruses should be considered in conjunction with other protocols to increase NK cells and Killer T cells (CD8s) which are the only known immune cells found to be functional against the two AIDS viruses. There is no evidence that the rate of cell destruction in the body is slowed down by increasing CD4 counts. The only immune cells that are effective against the two AIDS viruses are the Killer T cells (CD8) and the Natural Killer (NK) cells.
1. The HIV Drug Book, by Project Inform (Pocket Books).
Since 1984, our attention in the arena of AIDS has been mainly focused on HIV as the sole cause of AIDS with most PWAs, and even some medical doctors, using T4 Helper cell counts as the main indicator of immune function and AIDS progression. I count myself, along with the rest of the world, as being among the uninformed. Our lack of knowledge in the area of Immunology as well as our lack of understanding of what components of the immune system are effective in controlling the two viruses that causes AIDS has kept us in the dark ages. Thank, God, that finally, the truth has emerged. Now, it must be told to the world.
Recently, a long term PWA told me that 5 years ago, when his CD4 counts were in the 1600 range, he came down with PCP (Pneumocystis Carinii Pneumonia). In Aug., 1995, while I was interviewing David Stokes for an article on SPV-30, he told me about a friend who used thymic hormones to increase his CD4 counts up to 700. Shortly after this happened, he came down with PCP. Reports on the use of injectable Interluken II (IL2) significantly increasing CD4 counts published in GMHC newsletter have found no additional protection from opportunistic infections. GMHC wrote about several cases where persons with CD4 counts over 2000 were getting PCP and other infections. I have heard reliable reports of persons with Chronic Fatigue Syndrome (CFS) who were very sick with very high CD4 counts (over 1500). CFS is AIDS without HIV. Some CFS patients have also come down with PCP.
In AIDS, the antibody response fails to completely wipe out the invaders when the primary AIDS virus, African Swine Fever Virus (HHV-6A), infects newly formed B cells and the Antigen Presenting Cells (APC)s. For reasons unknown, but possibly do to the structure of this virus (HHV-6A), the B cells fail to create neutralizing antibodies against the virus. In other words, the newly formed B cells get infected with ASFV before they become Plasma cells. When these immature B cells produce antibodies, they are not effective against the virus because they are passive transfer antibodies (1). ASFV passive transfer antibodies later revert to active virus. This is why ASFV replication is not stopped by antibodies and viral replication continues. The preponderance of scientific evidence now indicates that functional CD4 cells in AIDS first requires B cells that can produce neutralizing antibodies against HHV-6A. This is not happening any more in humans than HHV-6A (African Swine Fever Virus) does in swine. In swine, the B cells also fail to produce neutralizing antibodies. However, there is evidence that the B cells are producing neutralizing antibodies against HIV in the blood, but the antibodies are not effective against cells infected with HIV. The infected cells are virus producing factories. To destroy cells infected with either or both viruses, HIV and HHV-6A, requires cell mediated immunity. In AIDS, this requires lots of CD8 and NK cells. Increasing the CD4s are not stopping the virus producing factories - the infected cells.
1. THE MERCK VETERINARY MANUAL
We must remember that when Robert Gallo first discovered HHV-6, he called it HBLV, which is Human B cell Lymphotropic Virus. The name was chosen because this virus infects B cells. This means that HBLV has a tropism for (was attracted to or by) B cell lymphocytes. However, other researchers like Knox and Carrigan (Medical College of Wis) have found that HHV-6A also has tropism for Dendritic Antigen Presenting cells in the lymph nodes. In contrast to HHV-6A, HIV is not known to have tropism for B cells. HIV has tropism for CD4 Helper cells.
At the onset of HHV-6A infection, the first cell groups to carry the greatest viral load are the Antigen Presenting Cells (APC) (monocytes/macrophages and Langerhans) and the Dendritic APCs in the germinal center of the lymph nodes as well as newly formed B cells. After their activity and function has been disrupted, NK cell activity declines, but for a different reason - namely a decrease in methionine-enkephalin, an endorphin that regulates NK activity. The next event is an increase in the CD8 cells (suppressor and Killer-T cells) which is then followed by a decline in the CD4s.
The increase in the CD8s is the first immune response that begins to slow down the replication of the two AIDS viruses - HHV-6A and HIV. Some CD8 cells are known as Cytotoxic Killer cells or Killer T cells. These cells have shown an ability, along with Natural Killer (NK) cells, to destroy the virus factories - the infected cells. There is no clinical evidence to indicate that increasing CD4 counts has reduced replication of either of the two AIDS viruses or slowed down the rate of cell destruction.
Other B cells known as memory cells retain the ability to produce effective antibodies against infections the person previously acquired (before being infected with ASFV). However, because of a failure of cell mediated immunity, these antibodies only provide protection in the peripheral blood (i.e. the common flu) and are not effective against infections in the cells like Cytomegalovirus (CMV) and mycobacterium avium complex (MAC) (1). Vaccinations often fail to provide protection in AIDS because of the failure of newly formed B cells (infected with ASFV), to produce effective antibodies using the antigens that were injected.
An example was a PWA who told me that two months after he received a vaccination for Hepatitis B, his blood showed no antibodies to the Hepatitis B virus. This is a failure of B cell and Antigen Presenting cell function.
1. Scientist Rethinks AIDS Immmunology, by Billi Goldberg and Randy Peters.
Reports of long term survivors with little or no CD4 (T4) counts have circulated for years. In 1994, a PWA from Chicago told me his CD4 count has been zero for the past 3 years and he feels fine. A PWA from Green Bay, WI, told me of a friend in San Francisco who has had no T4 cells for 10 years and is alive and healthy. What is keeping these people going?
Early in 1995, I had a discussion with Tom, a retired physician from Key West, FL, who is himself HIV+. I discussed with him lab results of certain protocols where CD4 counts had increased or decreased. His reaction puzzled me when he said: I dont know if I believe these lab test results....everyone is concerned with CD4 counts. I personally have several friends who are alive and healthy and have been for years...with CD4 counts of zero.
I asked him: why do we not look at the lab test results of PWAs with zero CD4 counts who can actively fight off infections without the help of drugs and find out what the difference is between them and those who are susceptible to every infection that comes down the pike?....Could it be that the person with zero CD4 (Helper cells) who has a functional immune system has high levels of other immune cells that are providing a functional immune system, like White Blood cells, high levels of Neutrophils, Monocytes, Macrophages, Natural Killer cells and CD8s?
Tom replied: That is a good question....if we had spent some of those billions of dollars of AIDS research money on learning how the immune system works, we probably would have found the answer to AIDS by now...we are spending too much money on long term studies of this drug or that drug and not enough to enhance our basic understanding of how the immune system functions, interacts with other components and those portions of it that can function independently.
Mark: Why arent medical doctors, the CDC, the FDA and others taking a serious look at the drug Neupogen (by Amgen), which has been available for years to build up the white blood cells? Would not one drug that builds up and restores a functional immune system be better than pouring a dozen or so drugs with toxic side effects into the body to kill this or that infection? The patient would certainly feel a lot better.
A vaccination for a virus (i.e. Hepatitis B) that does not result in new circulating antibodies in your blood is an indication that you do not have cell mediated immunity. MultiTest, a low cost skin test can give you a good indication if you have cell-mediated immunity and whether or not your immune system can respond to new opportunistic infections.
The skin test is a patch with several antigens (a dead piece of protein material from different viruses or bacteria) that painlessly pricks into your skin. After several days, there should be a skin reaction (red dots forming) that indicates that your immune system is producing antibodies against the antigens. If you have a strong reaction, you have good cell-mediated immunity. If you have a mild reaction, you have poor cell-mediated immunity and if you have no reaction, you have no cell mediated immunity.
This test is available from your physician. It is a useful tool to do at the beginning of a new protocol and after 2 or 3 months to see if cell-mediated immunity is returning. Ask for the Multitest skin patch that determines delayed type hypersensitivity reactions to antigens.
For some time, I have been searching for a single source in one book or publication that gives broad as well as detailed information on the components of the immune system and how they function. HOW YOUR IMMUNE SYSTEM WORKS is the only comprehensive book I have located to date on the immune system. The 153 page book is loaded with illustrations on the various subsets of immune system cells and how they interact and some unique components that act alone as infection fighters.
1. HOW YOUR IMMUNE SYSTEM WORKS, by Ziff-Davis Press, 5903 Christie Ave, Emeryville, CA 94608. Ph No. 800-688-0448
The very first line of immune defense is complement, a substance that circulates in the blood that coats viruses and other antigens and tries to damage their membranes by poking holes in it as well as changing the shape of the virus. Antibodies attached to viruses are known to stimulate complement production. Complement helps immune cells to identify enemy invaders for destruction even when antibody function is insufficient. Complement, a sticky substance, can help other immune cells identify viruses for destruction. However, there is little research material available on the subject of Complement.
If we learned how to increase Complement production, it would be a tremendous help to the immune cells (macrophages etc.) to identify the two AIDS viruses in the blood and destroy them. Complement does not react with normal cell membranes. The only sticky dietary supplement I know of is lecithin. Would taking lecithin daily increase production of Complement? In the 1980s, there was considerable interest in a compound formulated from egg-yolk lecithin called AL721. Perhaps, research with the use of lecithin was too quickly abandoned. Triple strength lecithin is sold in capsule form in health food stores. The use of lecithin in the treatment of AIDS/CFS should be investigated further.
Dr. Baggish sums up what I had long suspected when he said; White blood cells ...are the backbone of the immune system. White blood cells, like red blood cells, originate in the bone marrow. White blood cells (WBC), as a whole, comprise nearly all the immune cells in our body. WBCs are divided into three general categories: The first group is linked to Humoral Immunity which are the B cells. Some B cells mature into Plasma cells which produce antibodies. The second group is linked to Cell Mediated Immunity and comprises the T cells. These include the T cells subsets such as CD4 (Helper or inflammatory) and the CD8 (Suppressor or Killer-T cells). The third group of cells is called non-specific effector cells. These include neutrophils, monocytes, macrophages and Natural Killer (NK) cells.
Non-specific effector cells can work more effectively with the B cells and T cells to devour foreign invaders but can also work without them, though less effectively. NK cells can operate totally independent of any other immune cells and do not need their assistance to locate and destroy foreign invaders. NK cells are effective against viruses, fungus, bacteria, cancer cells as well as HHV-6A and HIV. NK cells can do more than just reduce viral load in the blood, they can locate and destroy cells infected with viruses.
While the antibody (inflammatory) responses are active, the NK cell activity is suppressed. The humoral (B cells) and cell-mediated immune responses (T cells) take over to try to quickly wipe out the invading enemy. These inflammatory responses include fevers and the massive production of new B cells. Some B cells evolve into Plasma cells that produce the antibodies. The B cells are like foot soldiers who tag enemies for future destruction. Once the virus is tagged with an antibody, the CD4 cells signal other immune cells (macrophages, monocytes and neutrophils) to come in and devour them. In AIDS, this inflammatory response results in swollen lymph nodes.
In the presence of HBLV(HHV-6A), more immune cells are stimulated into presenting the CD4 receptor. However, the CD4 receptor allows both HIV and HHV-6A an opening to invade the cell. As research previously discussed has shown, this increases HIV replication 15 fold. When a macrophage finds a virus, they swallow it and then present part of the enemy (virus etc.) to a Helper T cell (CD4). The Helper T cell then signals the macrophage to digest the enemy it has swallowed. The macrophage can also present the antigen to a Killer T cell or a Natural Killer cell. The antigen helps these immune cells identify and target them for destruction.
Dr. Patricia Salvato MD, in several published abstracts noted that AIDS patients, with high CD8 counts, maintained good health for years. Several other researchers have noted the link between high CD8 counts and long term survival.
A world renowned immunologist, Jay Levy, writing in The Lancet, June 24, 1995, said: Within the host, anti-cellular activity (against infected cells) must be elicited and can be achieved by NK or CD8+ cell antiviral response that suppresses viral replication at the transcription level....long-term symptom-free survival of individuals with HIV infection illustrates how this cellular antiviral activity affect virus/host....HIV has limited effects on the physiological processes in the host because of strong CD8+ cell responses directed against virus-infected cells.
In other words, what Jay Levy is saying is that persons with AIDS need high levels and activity of NK and/or CD8s to stop the disease progression as the NK and CD8 cells can destroy cells infected with the virus. In his report, Levy emphasized that existing drugs to treat AIDS only deal with free virus in the blood and not virus in the infected cells. The infected cells are virus producing factories. Unfortunately, drugs like AZT and other look a likes, are known to suppress CD8 cell counts.
A significant number of CD8s become Killer T cells and if CD8 counts remain high enough , they can keep a person relatively free of infections and symptoms for a long time - several years. The Killer T cells (CD8s) kill cells infected with a virus by being signaled by the infected cell through a molecule called MHC, Class I, which transports part of the virus to the surface of the cell to flag down a Killer T cell. (1) The Killer T cell sees the infected cell in distress and proceeds to kill it.
1. HOW YOUR IMMUNE SYSTEM WORKS, by Jeff Baggish M.D.
CD8 and NK cells are the best of both the first and the last line of defense against AIDS. Without the protection of high CD8s or active NK cells, the person becomes vulnerable to opportunistic infections. The only substance known to activate higher CD8 counts is a substance called DNCB, which is applied topically. The NK cells, the marines of the immune system, that have been asleep in their barracks, can be awakened with a drug called Naltrexone, taken once daily in a 3 mg dose. Dr. Bihari, who has prescribed Naltrexone for 8 years to his AIDS patients, reports that it triples the NK cells and stops AIDS progression.
Natural products that increase NK cell activity are Essiac tea (an anti-cancer tea that originally came from the Ojibwa Indian), and aged garlic extract and/or raw garlic. A daily drink made from a whole lemon, olive oil with lecithin added has been shown to have immense value in both AIDS and CFS quickly relieving a wide range of symptoms. The most effective treatment is a combination of several of the above.
Do not rely solely on an I.D. (infectious disease) physician. Find an Immunologist. Look in your local Yellow Pages phone directory under Immunology to find a medical doctor who has training in the arena of immune function. Two tests not frequently done that you need to ask for are the Total Absolute Natural Killer Cell count (CD 56+, CD16+ and CD3-) as well as MultiTest, a skin test for delayed type hypersensitivity (DTH) reactions that determines to what extent you have or do not have cell-mediated immunity. More information on monitoring lab results will be found at the end of the next chapter which discusses high priority treatment options.
Essiac Tea was first formulated in Canada in the 1920's by Renee Caisse, who obtained her original formula from a patient who recovered from breast cancer who claimed to have been cured by local native Indians. The tea has become a legend in its own time as a cure for Cancer. It contains Sheep Sorrel, Indian Rhubarb, Burdock and Slippery Elm. Ralph Moss in his book, Cancer Therapy, (Equinox Therapy, NY), reports on tests that show Burdock kills HIV in vitro.
In May, 1993, I talked to Al Mathieu of Tampa, FL, who claimed to have three friends who are long term AIDS survivors who feel well and he said they - "all used "Essiac Tea and have used it for several years." Al told me he has used various brands of Essiac tea for the past 4 years and is very pleased with the results he has obtained from the Herbal Harvest formula. He did not know his NK counts but reported a T8 count of 1050 and a CD4 count of 922 recently. He takes 1/4th cup (2 ozs) twice a day. He claims Essiac tea is all he has used for 4 years. Al told me he always boiled up his own batches at home. He tried several brands of premade liquid solutions and considered them not to be as effective. He also tried the original Essiac formula from Canada. The results he has obtained for the past 4 years are impressive. He told me that he considers the Herbal Harvest Formula to be the best product on the market for the price.
In Dec., 1995, I received a letter from a PWA who had zero NK cells. She reported that after using Essiac tea for 2 months, her NK function was now in the low end of the normal reference range. Sheep Sorrel, a key ingredient in Essiac stimulates complement activity(1). Complement is a substance circulating in the blood that punctures hole in viruses and makes them more easily seen and identified by immune cells.
Note: a cancer patient I spoke with in Nov., 1995, said she tried several versions of Essiac tea made by different companies, but found that the original Essiac tea (from Essiac, Intl Canada) gave her the best results in terms of pain relief and well being. She said that while competitors sold the same ingredients at lower prices, they did not know when to harvest the herbs at the proper time to obtain the maximum potency of active ingredients. She said: I tried various cheaper brands of Essiac to save money, but they did not relieve the pain.
Note: for cancer and KS, the suggested dose for the first 3 months is 3/4 cup daily. After this, reduce the dose to 1/4 cup twice daily. A batch of Essiac tea is made by boiling it with distilled water. 1. Hitoshi Ito, Japan J. Pharmacol, 40, 435-443 (1986)
The original Essiac formula which Rene Caisse received from the Ojibwa Indians in the 1920s is available from Essiac Intl - Ph. No. 613-837-3673. Essiac Intl, 2211-1081 Ambleside Dr., Ottawa, Ontario K2B 8C8. Some health food stores carry the original Essiac formula. It costs about $40 for one ounce, a 12 day supply, or about $100. a month.
A low cost formula (Ojibwa Indian tea) with the same 4 herbs is available from Herbal Harvest, RR2, Box 2727, Cambridge, VT 05444 Ph No 802-644-8850. Herbal Harvest Formula costs $40.00 a lb plus $3.00 for shipping ($43.00 total). This is a 4 month supply. It cost about $11.00 a month.
There is a lot of competition in the market place. I advise against buying liquid extracts of Essiac tea or capsules. When boiling the herbs, make no more than a 30 day supply at one time and refrigerate it after it is made. It is important to follow procedures that are known to be effective and not to go for the convenience of premade solutions or capsules which are not proven to be as efficacious.
For PWAs on limited income, and based on this PWAs recommendations and experience, the Herbal Harvest brand may be a good choice unless something better and equally cost effective comes along. On the other hand, if money is not a problem, try the Essiac brand from Essiac Intl in Canada and compare the results you get from this formula over a 3 month period with the Herbal Harvest brand over the same time period. Let us know if there is a difference in terms of lab results on increasing NK counts. Based on limited data, I consider both formulas to be good choices for stimulating NK activity. I do not have sufficient data, at this time, to make a final recommendation or endorsement.
You have the bare minimum profile for survival if your CD8 count is 600 or higher and your Total Absolute NK count is 100 cell per UL (cubic millimeter of blood) or higher and your WBCs are 4000 or higher.
Your immune system is slowing gaining strength if your Total Absolute NK count is 150 or higher and your CD8 are 1000 or higher and your WBC counts is over 5000 and if tests for the rate of cell destruction (Neopterin, beta2 microglobulin or Sedementation Rate) indicate that it is declining.
Your immune system is rapidly gaining strength if your total NK count is in the 200 to 300 range, your CD8 count is in the 1000 to 2000 range and your WBC count is over 6000. Both HHV-6A and HIV as measured by PCR should be dropping rapidly. Your CD4 counts should be moving back to a normal reference range. If you can get your NK count over 300, there is a possibility for a complete remissio providing that NK function is also restored. There is a possibility that a combination of Naltrexone, DNCB, Essiac tea, Garlic and the Whole Lemon drink may accomplish this feat. Naltrexone triples NK cell function. If you already have high NK cells, you still may need Naltrexone to increase NK activity and function. Increasing NK numbers is not a guarantee that function also increases. There are two distinct types of tests for NK cells. 1. Absolute NK cell counts and second, a NK cell function test. Note: only specialized labs can do the NK function test. Most labs can do a quantitative test for total absolute NK cell counts (CD56+, CD16+ and CD3-).
Trying to increase CD4 counts before you first increase NK, CD8 and WBC counts is both foolish and counterproductive. Only after your NK count is 200 or higher and function is restored and your CD8 count is 1000 or higher and your WBC count is 5000 or higher should you consider protocols to increase the CD4s. The question of whether you should use colostrum is now open as we do not know its effects on NK or CD8s.
There are four basic minimum goals that need to be addressed to reverse immune dysfunction from HHV-6A/HIV progression and other causes. They are:
1. To restore Natural Killer cells to their normal reference range and to use protocols to increase NK cell counts to as high a level as can be reached.
2. To increase CD8 counts to 1000 or higher (up to 3000). Remember, you are in danger of having opportunistic infections when they drop below 550.
3. To build up White Blood Cells, the foundation of the immune system with a goal of 7000 cells/UL. You are in danger if they drop below 4000. If WBCs are low, consider Castor oil, Vitamin A and Sun Tanning. Most of the important diet, attitude and lifestyle changes and detoxifying techniques are discussed in How To Reverse Immune Dysfunction, so I will not repeat them here.
Note: If your HIV viral load as measured by PCR is over 10,000, then take Clarkia-100 (50 drops 3 times a day in water) or take the same herbs in capsule form. The three herbs are green-black walnut extract, cloves and wormwood. A suggested pattern is 4 days on and 3 days off. If you want a more aggressive protocol, do it daily. However, some persons have reported excessive urination after doing this for several months. There are now over 50 documented cases of persons being negative for P24 antigen after using these three herbs for 6 to 8 weeks. One PWA who used Clarkia-100 for 4 months and the Whole lemon drink for the past 12, reports he is now PCR negative.
- 1. CD4 count is above 500 and you are asymptomatic: Naltrexone. Adult dosage: Take 3 mg daily before bedtime. If your CD8 counts are below 1000 cells/UL, add DNCB topical weekly treatments to further increase your CD8s.
2. CD4 count is between 200 and 500 and you are asymptomatic: Naltrexone, DNCB and the Whole Lemon Drink. Beta Carotene - 50 mg 3X and a good B vitamin formula - liquid or capsule. B-12 sublingual. For even better results, add Essiac tea and/or aged Kyolic Garlic capsules.
3. CD4 count between 100 and 200 and you are asymptomatic: Naltrexone, DNCB, Garlic and/or Essiac tea plus and the Whole Lemon Drink plus Beta Carotene - 50 mg 3X and a good B vitamin formula - liquid or capsule. B-12 sublingual. and one SEES-2000 daily to prevent PCP and 500 to 1000 mg daily of BHT dissolved in olive oil to prevent CMV. BHT is a powerful anti-oxidant sold in health food stores by Twinlabs. Consider adding it to the Whole lemon/olive oil drink daily. Other supplements to prevent or help treat Retinitis are Lutein (antioxidant) Use 40 mg twice daily (Twinlabs) plus Bilberry - 300 to 500 mg. daily. Follow the diet in How to Reverse Immune Dysfunction.
4. CD4 count is between 0 and 100 and you are asymptomatic: Do everything the group between 100 ands 200 does and add the following: a 4x6x1/2 inch ceramic magnet under your pillow. More information on north pole magnets can be found in the next chapter.
Naturally, if you have symptoms, you need to review the chapter on Symptoms and Remedies. Review this book and amend your protocol as needed. Add nutritional supplements, colon cleaning and the suggested diet as well as consult with your Physician.
DNCB Treatment Group, 2261 Market St, #436, San Frnacisco, CA 94114.
Several persons have reported having difficulty convincing their local physician to give them a prescription for Naltrexone. Dr. John Pittman MD, of Raleigh, NC, has agreed to provide a prescription for Naltrexone in conjunction with a telephone consultation, providing that is all that is needed. You can arrange a phone conference with Dr. Pittman by calling 800-473-9812. Prescriptions for 30, 60 or 90 capsules in 3 mg doses can be filled by contacting Bigelow Pharmacy at 212-533-2700.
Item 2. Dr. Philip Princetta of Atlanta, GA, is following 35 clients using the herb SEES-2000 to prevent PCP. There are no reports of anyone coming down with PCP who is taking one capsule per day. However, Dr. Princetta has reported five clients developed a rash after using the product a few days. All five discontinued using the product until the rash was gone. All five have since resumed using SEES-2000 and the rash has not returned.
Item 3. Three persons using the product, Clarkia-100, have reported that, after being on the it for several weeks, a problem of constant urination. I advised them to discontinue using Clarkia-100 until the frequency of urination returned to normal. Persons having a problem with excess urination using Clarkia-100 might want to try an intermittent protocol - 4 days on and 3 days off.
Item 4. Several persons are reporting a more rapid remission of symptoms with the whole lemon drink by adding one tablespoon of lecithin granules in place of the olive oil. In addition to these reports, my own research indicates that lecithin may have a more beneficial role than olive oil in the treatment of AIDS and CFS.
SEES-2000, the herbal product for preventing and treating PCP is now available. No outbreaks of PCP have been reported in 10 PWAs who have been the product for the past 3 months. Three PWAs who were hospitalized with PCP and who never had used SEES-2000 tried it in the hospital for the first time along with antibiotic therapy. All 3 patients recovered so rapidly that they were discharged from the hospital in 5 days. As for adverse effects, one person developed a rash (an allergic reaction) after using, SEES-2000 for ten days and discontinued using it. The rash cleared up in about 5 days. Last month I reported one case where a PWA using the new castor oil protocol had a decline in his WBC count when he added Septra to his protocol to prevent PCP. After dropping Septra and switching to SEES-2000 and continuing with the castor oil heat pad method 3 times a week, he told me his WBC count doubled in 3 weeks. He is also using Naltrexone, Clarkia-100 and SPV-30 and the whole lemon drink daily. After one month, he says he feels a million times better. Some people have had difficulty obtaining Naltrexone in 3 mg capsules from their local pharmacy since it has to be compounded and encapsulated. One pharmacy that will fill your prescription through the mail is Bigelow Pharmacy in New York. There phone number is 212-533-2700. The cost is $24.00 for 30 capsules. Oralmat, the immune modulator from Australia, was tested by 7 PWAs in the past 30 days. All persons with fatigue reported feeling a natural burst of energy and a better sense of well being. Two persons said it got rid of a cold overnight and the flu in 24 hours. If you are interested in trying Oralmat, leave your phone number and I will place you in contact with sources.
With the new castor oil protocol announced in Report No 9, seven people have now reported significant increases in total white blood cell counts and increases in CD4s as well. However, there was a setback in one case when a PWA added the drug, Septra, at his Physicians suggestion, to prevent PCP. After 4 weeks on Septra, both WBC and CD4 counts dropped even though he was doing the new castor oil protocol which had helped produce very positive results in the previous 4 weeks. When he checked a medical reference book for the side effects of Septra, he found it listed along with Bactrim under a group of drugs known as Sulfonamides. The side effects listed for both drugs commonly used to prevent PCP includes both anemia and leukopenia which translates into low red and white blood cell counts. This means that Bactrim and Septra may depress your immune system when used daily as a prophylaxis to prevent PCP. An alternative to these drugs is SEES-2000, a special herbal formulation I wrote about in Report No 9. A new source for obtaining SEES-2000 is Dr. Philip Princetta of Atlanta, GA. Also, any local source that sells LDM-100 and/or Clarkia-100 can also obtain SEES-2000, since all three products are manufactured by the Secret Herb Gardens (former Spice West Co).
Natur-Earth is a product that has useful concentrations of Lactoferrin, an ingredient also found in Colostrum. Lactoferrin has an affinity for sequestering iron in the body and making it available to the cells and especially the hemoglobin. By sequestering iron, lactoferrin prevents it from being used by viruses, fungus and bacteria in their metabolic life process, thus inhibiting replication of these pathogens. Lacteferrin is thus valuable in inhibiting the replication of HIV and all other viruses, fungal and bacterial infections in the body. These pathogens need iron to replicate and exist. Inorganic iron, not bound to lactoferrin, is available to viruses, fungal and bacteria for their replication whereas iron bound to the amino acids in lactoferrin is only available to the body's cells when needed. Confidential clinical studies done with Natur-Earth has found it to be effective in most chronic conditions of viral and fungal infections, chronic fatigue syndrome and some forms of leukemia.
There are unconfirmed reports of increases in T cell counts in PWAs with its regular use and of significant benefits to persons with CFS. This product should be considered by persons with HIV, chronic fatigue syndrome, any chronic infection not responding to the current therapy, candidiasis as well as cancer and leukemia patients as an adjunct therapy. Dosage: 3 capsules should be taken with a full glass of water up to 1/2 hr. before meals three times a day. After 30 days, the dose is reduced to 2 capsules 3X and in the third month 1 capsule 3X. A bottle of 90 capsules can be ordered from Jim Jordan, 5110 Williams Fork Trail, Apt 207, Boulder, CO 80301. (Ph No. 303-530-9826) Cost $40 for one 90 capsule bottle which includes postage. The manufacturer can be reached in Albq, NM at 505-266-7374.
Oralmat, the immune modulator from Australia, was tested by 7 PWAs in Nov-Dec., 1995. It is made from wild rye (secale cereale). All persons with fatigue reported feeling a natural burst of energy and a better sense of well being. Two persons said it got rid of a cold overnight and the flu in 24 hours. The product is taken 3 drops under the tongue, three times a day. ACNO is an excellent treatment for herpes, skins rashes and ACNE. ACNO is a cream with secale cereale applied topically. If you are interested in trying either Oralmat or ANCO for personal use, contact Dr. Philip Princetta in Atlanta, GA. He can be reached at 404-873-6888. An Australian distributor, Jan Goroncy of Natural Therapy Products, may be reached at 011-612-447-552 in the evening or send a FAX 011-612-983-1686.
A definitive work on the history and practice of Lymphatic massage. The author told me he successfully treated Lymphadenopathy in a patient with Chronic Fatigue Syndrome for 15 years. Many chronic conditions that do not respond to conventional therapy can be treated successfully with lymphatic massage. Dr. William Brown Ph.D. offers private instructions on how to do lymphatic massage. His manual The Touch That Heals is available from Tal San Publishing. 602-843-1119. ISBN 1-884298-07-9
Jan 15, 1996: Robert M of Brooklyn , NY called to tell of a new product that almost reduced his lymph nodes to normal size in 3 days. It is called Phyto-Life It contains a number of green food products and herbs. It is manufactured by Higher Ideals. 800-636-8644. The cost is $10.00 a bottle. Dose: Two tablets 2X a day is suggested.
Rodessa Vespas daughter died of AIDS related complications late in 1995. A non-profit foundation has been set up in her memory to help children and others seeking financial help for paying the cost of nutritional/holistic AIDS therapies. For more information, contact the Codi Vespa Foundation, 9957 N Alpine Rd #102, Machesney Park, IL 61115 Ph No. 815-636-0872.
It would be naive for anyone to think that all treatments that are presented under the banner of alternative AIDS therapies are good or trustworthy. I recently learned of a scam in Mexico where they are offering to cure you of AIDS for $15.000. When a PWA asked the source for documentation, they said they had been sent it to New Zealand for review. When asked if they had made a photocopy of the documentation, they were told that it costs money to print copies. The PWA replied: Yes, 5 cents a copy.
Unfortunately, some patients and even some health care practitioners are taken in by fast talking and convincing con artists. You can always tell a scam by their hurry to get your money and their unsubstantiated claims. I am not even talking about double blind studies. I am talking about their failure to provide documentation on anecdotal cases. Where are the names and phone numbers of all these cured patients? Where are the lab test results? I wish I knew of a quick cure for AIDS. There is none. I am hopeful that a slow cure can be found by bringing NK and CD8 immune cells to the highest possible state of activity. Until that happens, let the buyer beware.
15,000 copies of this newsletter have been printed for national distribution. 5000 copies have been set aside for free distribution. If you belong to a PWA support group or know of a local AIDS service organization where copies may be displayed, write or call us for the number of copies you will need. Minimum request is 10 copies; the maximum is 500.
A special thanks for the many hundreds of small and large donations received from our readers. Your support makes possible our continuing efforts. A special thanks to those of you who recite daily the Pieta Prayers. Prayer does make a difference. It heals us spiritually, emotionally and physically and it Keeps Hope Alive. Mark Konlee
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